Saffr-Tone Full Spectrum Saffron 60 caps by Paradise Herbs

Oral saffron extract seems to reduce eye pressure in glaucoma, according to several studies. The most recent result was reported at the World Ophthalmology Congress 2014 Tokyo. In this report, the intraocular pressure (IOP) reduction became evident after three weeks of therapy.

  • Saffron may reduce eye pressure (IOP) in glaucoma**
  • Saffron has shown ocular hypotensive effect in glaucoma studies
  • Saffron is rich in carotenoids
  • Saffron protects neurons in certain situations**
  • Saffron suppressed inflammation in multiple sclerosis research**
  • Potential treatment for diseases involving neuroinflammation, such as multiple sclerosis or glaucoma**
  • Crocin, a compound in saffron, exerts a protective effect in brain cell cultures**

Saffr-Tone comes from our word saffrotonin which comes from the word serotonin. Our truly holistic full spectrum saffron is the highest quality nature has to offer and retains the true essence and breadth of the whole herb the way nature intended.**

Saffron is a powerful herb traditionally used to help support  cheerfulness, positive mood, harmony and balance. According to Ayurveda when one is in harmony and balance they sleep better, are less stressed and tend to make better food choices therefore maintaining a more healthy body weight.**

  • 100% Pure
  • Super Potent Eye Formula
  • Dietary Supplement
  • Enhancing Nature's Materials Since 1994
  • True Full Spectrum
  • Naturally Extracted
  • No Added Fillers/Flows
  • No Toxic Solvents
  • No Harsh Chemicals
  • No Fractionizing Gases

Made The Way Nature Intended!

Saffr-Tone Full Spectrum Saffron

15 mg, 60 Vegetarian Capsule

Item Catalog Number: S830

Raw material: Saffron stigma extract containing a holistic full spectrum of active and synergistic constituents including saffranal, crocin and picrocrocin.
Suggested Use

Take one capsule twice daily (morning and evening) or as recommended by a healthcare practitioner.

Other Ingredients

Capsule (vegetable material), OptiMSM (methylsulfonylmethane), 100% vegetarian. No binders, fillers or common allergens.

Made the way nature intended!

No harsh chemicals. No toxic solvents. No isolating/fractionizing
Warnings

Keep in a cool dry place, out of the reach of children. Do not exceed recommended dose. Consult with your healthcare practitioner before using this product if you are taking any medication, anti-coagulant or anti-platelet medications or if you have a bleeding disorder or kidney disease. Avoid use during pregnancy.

Supplement Facts
Serving Size: 1 Vegetarian Capsule
  Amount Per Serving % Daily Value
Saffr-Tone saffron stigma extract (Crocus sativus L.) (naturally containing 2% safranal by uv vis) 15 mg *
* Daily Value not established.

**DISCLAIMER: Information on this page is not intended as a substitute for advice provided by a competent health care professional. You should not use this information in diagnosing or treating a health problem. No claim or opinion expressed on this web site is intended to be, nor should be construed to be, medical advice. If you are now taking any drugs, prescribed or not, or have a medical condition, please consult a competent physician who is aware of herb/drug interactions before taking any herbal supplements. The information presented herein has not been evaluated by the FDA or the Department of Health and is not intended to diagnose, prevent or treat any disease or illness.

The Ocular Hypotensive Effect of Saffron Extract in Primary Open-Angle Glaucoma: A Pilot Study

Objective/Purpose
To evaluate the effect of aqueous saffron extract on intraocular pressure (IOP) in primary open-angle glaucoma (POAG).

Materials/Patients
Thirty-four eyes of 34 consecutive patients with POAG under treatment with topical timolol and dorzolamide, were randomized to receive 30 mg/d aqueous saffron extract for one month (17 eyes) While the other 17 eyes served as the control group. Following the treatment period, both groups entered a one-month wash-out period. Main outcome measure was IOP during treatment period and after the wash-out period

Methods
Prospective, comparative, randomized interventional case series

Results and Conclusion
Mean baseline IOP (Corneal thickness adjusted IOP) before intervention was 14.23±3.49 mmHg in the saffron group versus 15.52±2.18 mmHg in the control group (p=0.20). After three weeks of treatment, IOP was significantly decreased to 12.29±3.42mmHg in the saffron group as compared to 15.05 ± 2.13mmHg in the control group (p=0.008). At four weeks IOP was significantly lower in the saffron group (11.94±3.15 mmHg versus 15.35±1.86 mmHg in the saffron and control groups respectively, p=0.001). At the end of the wash-out period, IOP was 14.29±2.80 in the saffron group and 15.70±1.72 mmHg in the control group (p=0.086).

None of enrolled patients had adverse effects. Oral aqueous saffron extract seems to have ocular hypotensive effect in POAG. This effect became evident after three weeks of therapy.

 

NOTE: The demyelination and neuroinflammation described below are thought to have a lot in common with glaucoma.

Medical researchers make important research link between active ingredient in saffron and MS

Medical researchers at the University of Alberta have discovered that an active ingredient in the Persian spice saffron may be a potential treatment for diseases involving neuroinflammation, such as multiple sclerosis.

Chris Power and a team of researchers in the Faculty of Medicine & Dentistry recently published their findings in the peer-reviewed publication, The Journal of Immunology.

"We found there is a compound in saffron, known as crocin, that exerts a protective effect in brain cell cultures and other models of MS. It prevented damage to cells that make myelin in the brain," Power said. "Myelin is insulation around nerves. MS is characterized by inflamed brain cells that have lost this protective insulation, which ultimately leads to neurodegeneration."

Power noted they are not close to a clinical trial stage yet, but the finding is still exciting.

It has been known in the research community for years that crocin protected neurons in certain situations, but Power and his team wanted to delve further into this area.

His team discovered that inflammation and a specific type of cell stress are closely linked and lead to neurodegeneration and inflammation which cause cells to lose their protective coating – a process known as demyelination. In experiments conducted by Power and his colleagues, the use of crocin suppressed both inflammation and this specific type of cell stress, resulting in decreased neurological impairment in lab models and cell cultures with MS.

"There are still many questions to be answered about how crocin exerts these neuroprotective effects, but this research highlights a potential treatment role for crocin in diseases involving chronic neuroinflammation – something that had not been recognized until now," says Power.

He explained the research demonstrates a new mechanism in MS, provides new potential drug targets in the future, and helps explain why physicians see inflammation in MS.

The team's research also revealed that this specific type of cell stress, called the unfolded protein response, may be caused by an ancient virus that was introduced into the DNA of early humans. This particular cell stress is found at high levels in MS brain lesions.

"We all have this ancient virus in our DNA, but for some reason it is excessively turned on in MS," says Power. "We are doing more research investigating this link."

Power has been investigating this specific area for six to seven years.

source: http://www.eurekalert.org/pub_releases/2011-11/uoaf-mrm110311.php

About Paradise Herbs & Essentials®

Paradise Herbs & Essentials® Inc. was established in 1994 by our founder and formulator and has been family owned and operated ever since. With a combined experience of over 26 years of training, experience and research in the natural health foods industry along with our founders extensive background in Chinese, Ayurvedic and Euro-Native American herbalism we have established ourselves as a company with big ideas and even higher standards. Our founder has received over ten years of apprentice hands-on training working directly under two Chinese medical doctors with a combined total experience of over sixty years in traditional Chinese medicine.*

At Paradise we know that the end product is only as good as your starting material. We obtain our herbs from special alliances we have built all over the world. Our herbs are grown where they are indigenous; either ethically and ecologically wild crafted or naturally cultivated without the use of any chemical fertilizers, pesticides or preservatives.*

For example: Our Ayurvedic herbs Turmeric, Ashwagandha and Holy Basil are from an isolated and pristine environment at the base of the Himalayans, or we obtain our Ginger from the Ecuadorian rain forest where it is ethically wild crafted. It is this total combination of factors: climate, soil, pristine and natural growing environment that produce the outstanding quality of all our herbs. But we don’t stop there.*

Our end product after extraction is a True Full Spectrum™ extract, although we measure standard marker compounds in most of our extracts we never fractionate or isolate.  We believe in keeping all the synergistic components in the balanced ratios nature intended. We know that in many cases it is not evident which components are to be credited for the clinical effect, or if several components must act synergistically, therefore the whole root extract is always regarded as the active ingredient.  It is a central philosophy of traditional herbalism to trust in the wisdom of nature to provide the most complete medicines for humans. Unlike the conventional Pharmaceutical Industry that has sought to isolate compounds to create new drugs, we believe the whole herb is the medicine and is supplying all the benefits.  For example, studies have shown that a True Full Spectrum™ herbal extract of Panax Ginseng consistently outperforms an extract comprising only isolated ginsenosides. This illustrates that polysaccharides and other active constituents in Ginseng play an integral role in its clinical efficacy. Also, research analysis reveals a component in Panax Ginseng called panaxydol to inhibit cell cycle progression of human malignant tumor cells. We believe this is scientific proof for True Full Spectrum™ preparations as compared to fractionated isolates only containing the ginsenosides and possibly lacking some of the benefits.*

Our production facility is NSF certified to meet all cGMP requirements according to FDA standards. All operations are carefully documented, including in-process quality assurance checks. Equipment use/cleaning logbooks, and standard operating procedures are followed scrupulously to avoid any form of contamination or non-compliance.*

HEPA filters not only condition the air by removing moisture, they function at 95% efficiency down to 5 microns, eliminating microbial and cross-contamination. This system introduces clean air into the room creating a positive pressure which ensures that only the cleanest air contacts ingredients and finished goods.*

WE NEVER USE FILLERS OR FLOW AGENTS. Common fillers or flow agents like magnesium stearate, calcium stearate or stearic acid are hydrogenated oils. Not only are these oils unhealthy, they coat the capsule ingredients with a layer of saturated fat hindering nutrient absorption. Some studies we have seen list this hindrance to be as high as 80%. Doing the math on this, that cuts down nutrient contents utilized to 20%, not very good to say the least.*

All labels conform to all applicable DSHEA labeling laws.*

These standards of excellence will leave you with a finished product you can feel safe and confident consuming.*

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.