Pycnogenol 100 mg 60 vcaps by Healthy Origins
100 mg, 60 Vegetarian Caps
Item Catalog Number: 41372
- Nature's Super Antioxidant
- Look, Feel, and Live Better
- French Maritime Pine Bark Extract
- Supports Normal Circulatory Health
- Suitable for Vegetarians
PYCNOGENOL article #1 by Robert Ritch, MD
Pycnogenol, an extract of French maritime pine bark (Pinus pinaster), is primarily composed of procyanidins and phenolic acids and is a potent antioxidant with strong free radical-scavenging activity against reactive oxygen and nitrogen species. Procyanidins are biopolymers of catechin and epicatechin subunits, which are important in human nutrition.(Rohdewald 2002)
Pycnogenol is effective in patients with venous microangiopathy (Cesarone et al. 2006) (Cesarone et al. 2006) and accelerates healing in leg ulcerations from chronic venous insufficiency(Belcaro et al. 2005) and diabetes.(Belcaro et al. 2006) In chronic venous insufficiency, pycnogenol reduced lower leg circumference and symptoms of pain, cramps, nighttime swelling, feeling of "heaviness", and reddening of the skin.(Koch 2002) Pycnogenol can protect vascular endothelial cells from Aß-induced injury.(Liu et al. 2000) It reversed elevation of serum creatinine, BUN, LDH, IL-1beta, IL-6, and TNF-alpha levels in ischemia reperfusion injury in unilaterally nephrectomized rats.(Ozer Sehirli et al. 2009)
Pretreatment with pycnogenol reduces smoke-induced platelet aggregation.(Araghi-Niknam et al. 2000) Pycnogenol significantly reduces LDL-cholesterol levels.(Devaraj et al. 2002; Koch 2002) A randomized controlled trial reported it effective for erectile dysfunction.(Stanislavov et al. 2007) It has also been reported to improve symptoms of jet lag.(Belcaro et al. 2008) It inhibits inhibits not only HIV-1 binding to host cells, but also its replication after entry in susceptible cells in vitro.(Feng et al. 2008) It has been reported to increase urinary catecholamines and ameliorate attention deficit hyperactivity disorder in children.(Dvoráková et al. 2007)
After oral administration of pycnogenol, plasma samples significantly inhibited NFkB activation and MMP-9 release from human monocytes, indicating that it exerts anti-inflammatory effects by inhibiting proinflammatory gene expression.(Grimm et al. 2006) Glutamate inhibits cyclo-oxygenases 1 and 2.(Schafer et al. 2006) This cytotoxicity was inhibited by both GBE and pycnogenol.(Kobayashi et al. 2000) Pycnogenol not only suppresses the generation of reactive oxygen species, but also attenuates caspase-3 activation and DNA fragmentation, suggesting protection against Aß-induced apoptosis.(Peng et al. 2002)
Pycnogenol has also been reported to inhibit angiotensin-converting enzyme and to enhance the microcirculation by increasing capillary permeability.(Packer et al. 1999) It inhibits progression of preproliferative diabetic retinopathy(Schonlau & Rohdewald 2001) and may reduce the risk of formation of both diabetic retinopathy and cataract.(Kamuren et al. 2006) More recently, in patients with mild to moderate retinal edema, pycnogenol treatment significantly improved both the edema and retinal thickness as measured by high resolution ultrasound.(Steigerwalt et al. 2009) Laser Doppler flow velocity measurements at the central retinal artery showed a statistically significant increase from 34 to 44 cm/s in the Pycnogenol group as compared to marginal effects in the control group.(Steigerwalt et al. 2009)
Steigerwalt et al(Steigerwalt et al. 2008) evaluated the effects of the food supplement Mirtogenol (Mirtoselect and Pycnogenol on IOP and ocular blood flow in 20 subjects versus 18 controls. After three months of treatment, the IOP was lowered compared to that of untreated controls from a baseline of 25.2 mmHg to 22.0 mmHg (p<0.05). Ocular blood flow (central retinal, ophthalmic, and posterior ciliary arteries) improved both in the systolic and diastolic components as measured by Color Doppler imaging.
See references here:
Non-pharmaceutical medications and approaches to glaucoma (all articles) | FitEyes.com
PYCNOGENOL article #2 submitted by Robert Ritch, MD
Pycnogenol is rich in procyanidins, which may help to provide protection from cell-damaging free radicals. Pycnogenol is naturally derived from french maritime pine bark.
Pycnogenol, an extract of French maritime pine bark (Pinus pinaster), primarily composed of procyanidins and phenolic acids, is a potent antioxidant which has strong free radical-scavenging activity against reactive oxygen and nitrogen species. Procyanidins are biopolymers of catechin and epicatechin subunits which are recognized as important constituents in human nutrition.90 Pretreatment with pycnogenol reduces smoke-induced platelet aggregation.91 Pycnogenol significantly reduces LDL-cholesterol levels.92, 93 In patients with chronic venous insufficiency, circumference of the lower legs and symptoms of pain, cramps, night-time swelling, feeling of "heaviness", and reddening of the skin were reduced.93 In an animal model using a branding iron on rats, pycnogenol accelerated wound healing and reduced scar formation.94 Glutamate-induced cytotoxicity in HT-4 neuronal cells has been demonstrated to be due to oxidative stress caused by depletion of cellular glutathione (GSH). Extracts of Gingko biloba (EGb 761) and French maritime pine bark (Pycnogenol) were effective inhibitors of this cytotoxicity.95 Pycnogenol can protect vascular endothelial cells from Aß-induced injury, suggesting that it may be useful for the prevention and/or treatment of vascular or neurodegenerative diseases associated with Aß toxicity.96 PYC not only suppresses the generation of reactive oxygen species, but also attenuates caspase-3 activation and DNA fragmentation, suggesting protection against Aß-induced apoptosis.97 Pycnogenol has also been reported to have angiotensin-converting enzyme (ACE) inhibiting activity, and the ability to enhance the microcirculation by increasing capillary permeability.98 Pycnogenol inhibits the progression of diabetic retinopathy.99, 100 It also showed strong inhibitory effects on the activities of MMP-1, MMP-2, and MMP-9, suggesting a basis for its use in prophylaxis and therapy of disorders related to imbalanced or excessive MMP activity.101 In another interesting study, Pycnogenol treatment was effective in decreasing the number of deep and superficial vein thromboses in moderate-to-high risk subjects during long-haul flights.102
See references here:
Complementary Therapy for the Treatment of Glaucoma by Robert Ritch | FitEyes.com
Pycnogenol plus bilberry is the combination claimed to reduce intraocular pressure ("IOP" or eye pressure) in some research studies. See some of the discussion here:
Mirtogenol lowered elevated IOP | FitEyes.com
Effect of Bilberry and Pine Bark Extracts on Improving Ocular Blood Flow and Lowering IOP | FitEyes.com
Pycnogenol is a valuable antioxidant apart from any effect it may or may not have on eye pressure.
|Serving Size: 1 Vegetarian Capsule|
|Amount Per Serving||%DV|
|Pycnogenol (French Maritime Pine Bark Extract)||100 mg||†|
|†Daily Value not established.|
As a dietary supplement for adults, take one (1) vegetable capsule once or twice daily, preferably with a meal, or as directed by a physician.
Vegetable capsule (cellulose, water), l-Leucine.
Free of sugar, salt, starch, yeast, wheat, gluten, corn, soy, barley, fish, shellfish, nuts, tree nuts, egg and dairy products. No preservatives, artificial flavors or artificial colors.
Pycnogenol® is a registered trademark of Horphag Research LTD. Use of this product may be protected by one or more U.S. Patents and other International patents.*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.