Optimized Resveratrol 250 mg 60 vcaps by Life Extension

Optimized Resveratrol with Synergistic Grape-Berry Actives

250 mg - 60 Veg Capsules
Item catalog number: 01430

  • Mega Potency
  • Cardiovascular Support
  • Foundation For Longer Life
  • Full-Spectrum Trans-Resveratrol Formula
  • Dietary Supplement
  • PTeroPure

Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. It is found in red wine, grapes, blueberries and other berries. Resveratrol also has additional neuroprotective effects that may be beneficial to glaucoma beyond the benefits to the trabecular meshwork.

Resveratrol is a polyphenol naturally found in the skin of red grapes, certain berries, and other plants. Recent research has shown that Resveratrol can help to support healthy cardiovascular function. Resveratrol is best known for its cellular antiaging properties, as well as for its ability to promote a healthy response to biological stress.*

Life Extension has identified certain compounds that mimic calorie restriction’s ability to trigger youthful gene expression, the process by which genes transmit signals that slow certain aspects of aging. These compounds include trans-resveratrol (which researchers contend is the most active constituent), whole grape extract, quercetin, plus certain compounds found in berries, including trans-pterostilbene and now fisetin.

Findings from published scientific literature indicate that resveratrol may be the most effective compound for maintaining optimal health and promoting longevity.144 Resveratrol is a phytoalexin, a polyphenolic compound which is produced by Vitis vinifera as a response to attack by molds. Because of the widespread use of pesticides in modern wine making, including the practice of copper sulfation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement.

Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of resveratrol’s positive benefits including promoting healthy insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the effects of a high-fat diet.145-159

Life Extension has evaluated published studies on resveratrol to establish the doses humans might need to take to duplicate the remarkable laboratory findings. The results of Life Extension’s analysis yield a wide range of potentially effective doses: from 20 to 250 mg a day and higher. The resveratrol potency you choose may be based on your current state of health and/or your desire to reach the upper limits of a healthy human life span.

Pterostilbene, a stilbene compound from the same family as resveratrol, has been shown to work synergistically with resveratrol, to unlock one’s longevity genes … thus conferring even greater anti-aging benefits. In laboratory tests, pterostilbene has shown promise for supporting cardiovascular health, glucose levels that are already within normal range, anti-aging and cognitive function.178-185 It helps improve mitochondrial function and supports healthy metabolic function by activating SIRT1 and mimicking calorie restriction.186,187 It has also shown potential to ease inflammation and support antioxidant activity.181,185

Fisetin, found in strawberries, has the power to “switch on” cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.160 Fisetin also supports aging neurons in the presence of oxidative stress.161-165 And, most importantly, it works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown,166 thus extending its beneficial effects! So naturally we added it, along with these other four calorie restriction mimics, to this most advanced resveratrol formulation.


Suggested Use

Read the entire label and follow the directions carefully prior to use.

Take one (1) capsule daily with or without food, or as recommended by a healthcare practitioner.

Other Ingredients

Vegetable cellulose (capsule), silica, vegetable stearate, maltodextrin.

Warnings

Caution: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

  • Keep out of reach of children.
  • Do not exceed recommended dose.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Store tightly closed in a cool, dry place.

Supplement Facts

Serving Size 1 vegetarian capsule

Servings Per Container 60

Amount Per Serving

Trans-Resveratrol [from Japanese knotweed (root) and whole red grape extracts] [also supplying glycosides (polydatin)]

250 mg

Red Grape (Full Spectrum French Red Wine Polyphenol Profile), Wild Blueberry, Japanese knotweed extract blend [supplying polyphenols, anthocyanins, OPCs, free resveratrol, resveratrol conjugates (epsilon-viniferin, trans and cis-polydatin), and resveratrol analogs (pterostilbene)]

85 mg

Quercetin (as quercetin dihydrate)

60 mg

Trans-Pterostilbene (from pTeroPure®)

0.5 mg

Fisetin [from (Rhus succedanea L.) extract (stem)]

10 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate, maltodextrin.

pTeroPure® is a registered trademark of ChromaDex, Inc.

Dosage and Use
  • Take one capsule daily with or without food, or as recommended by a healthcare practitioner.
Caution

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

Warnings
  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating

 

Resveratrol Article

by Robert Ritch, MD.

Resveratrol (3,5,40-trihydroxystilbene), a powerful polyphenolic antioxidant, is found largely in the skins of red grapes and berries and came to scientific attention as a possible explanation for the low incidence of heart disease among the French, who eat a relatively high-fat diet (the French paradox). Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD). Grape juice, which is not a fermented beverage, is not a significant source of resveratrol. A large number of studies in the past few years suggests its benefit in vitro and in vivo in a variety of human disease models, including cardioprotection, neuroprotection, immune regulation, and cancer chemoprevention. For an extensive review, see (Pervaiz & Holme 2009). Substantial data show that actions of resveratrol include inhibition of lipid peroxidation and platelet aggregation, metal chelating (primarily copper), free radical–scavenging activity, antiinflammatory activity, modulation of lipid metabolism, antifungal properties, and anticancer and estrogen-like activity.(Pervaiz & Holme 2009)

Resveratrol increases the lifespan of the yeast, Saccharomyces cerevisiae, the nematode, Caenorhabditis elegans, and the fruitfly, Drosophila melanogaster. It was later shown to extend the lifespan of the short-lived fish, Nothobranchius furzeri,(Valenzano & Cellerino 2006) and has now been shown to significantly increase the health and survival of mice on a high-calorie diet, pointing to a new approach to treating diseases of aging.(Baur et al. 2006) Among its multiple functions, resveratrol activates sirtuins (silent information regulator proteins), a family of proteins that play an important role in DNA repair, gene silencing, chromosomal stability and longevity.(Michan & Sinclair 2007)

The physiologic effects of resveratrol appear to be related to its ability to regulate nutrition and longevity genes.(Pervaiz & Holme 2009) Resveratrol is an effective antioxidant.(Frankel et al. 1993; Chanvitayapongs et al. 1997; Shigematsu et al. 2003) It inhibits lipid peroxidation of low-density lipoprotein (LDL), prevents the cytotoxicity of oxidized LDL, and protects cells against lipid peroxidation.(Chanvitayapongs et al. 1997) Resveratrol protects against the degeneration of neurons after axotomy.(Araki et al. 2004) A single infusion of resveratrol can elicit neuroprotective effects on cerebral ischemia-induced neuron damage through free radical scavenging and cerebral blood elevation due to nitric oxide release.(Lu et al. 2006) Its antiapoptotic activity has led to the suggestion that resveratrol may make a useful dietary supplement for minimizing oxidative injury in immune-perturbed states and human chronic degenerative diseases.(Losa 2003)

Levels of intracellular heme (iron-protoporphyrin IX), a pro-oxidant, increase after stroke. In neuronal cell cultures, resveratrol induces heme oxygenase 1, suggesting that increased heme oxygenase activity is a unique pathway by which resveratrol can exert its neuroprotective actions.(Zhuang et al. 2003)

Resveratrol directly inhibits CYP1B1. The versatility of RSV lies in its diverse targeting of membrane and intracellular receptors, signaling molecules, biogenesis enzymes, oxidative systems, DNA-repair mechanisms, and transcription factors, and it can activate or repress a number of signal-transducing pathways found throughout the cell (Pervaiz & Holme 2009)

There appears to be an association between aging and neurodegenerative diseases, such as Alzheimer’s, and that modulation by both caloric restriction and drugs which mimic caloric restriction, such as resveratrol, can ameliorate these diseases.(Liu et al. 2007) Resveratrol reduces the levels of secreted and intracellular amyloid-ß peptides by proteosomal degradation.(Marambaud et al. 2005)

In the eye, resveratrol suppresses selenite-induced oxidative stress and cataract formation in rats.(Doganay et al. 2006) The authors suggested that the presence of oxidative stress in selenite cataract development and its prevention by resveratrol support the possibility that high natural consumption of resveratrol in food can help prevent human senile cataract. Resveratrol also induces dilation of retinal arterioles, suggesting a potential benefit for this compound in the treatment of retinal vascular disease.(Nagaoka et al. 2007) Sirtuin-1 activators (such as resveratrol) demonstrate neuroprotective properties in mouse models of optic neuritis and multiple sclerosis.(Shindler et al. 2007)

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