Optimized Folate (L-Methylfolate) 1000 mcg 100 tabs by Life Extension

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function. Folate can lower plasma total homocysteine concentrations safely and inexpensively. Homocysteine is elevated in glaucoma.**

  • Emerging research indicates folate may be important for glaucoma
  • Metabolically Active Form of Folic Acid
  • Contains (6S)-5-Methyltetrahydrofolic acid (also called 5-MTHF) - the best form of supplemental folate
  • Studies also show that the effectiveness of folate can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), dibencozide, vitamin B6, and riboflavin.
  • Dietary Supplement

Optimized Folate (L-Methylfolate)

1000 mcg, 100 vegetarian tablets

Item Catalog Number: 01939

Suggested Use

1 vegetarian tablet one time daily or as directed by a qualified health care professional.

Supplement Facts

Serving Size 1 tablet

Servings Per Container 100

Amount Per Serving
Folate [as (6S)-5-Methyltetrahydrofolic acid, glucosamine salt]^ 1000 mcg

Other ingredients: microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.

^Quatrefolic® is a registered trademark of Gnosis S.p.A., Patent number 7,947,662.

Dosage and Use
  • Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.
  • New developments in DNA analysis and biochemistry suggest folate supplementation is important for individuals with certain common polymorphisms.
Non-GMO

 

Warnings
  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating

To report a serious adverse event or obtain product information, contact 1-866-280-2852

**DISCLAIMER: Information on this page is not intended as a substitute for advice provided by a competent health care professional. You should not use this information in diagnosing or treating a health problem. No claim or opinion expressed on this web site is intended to be, nor should be construed to be, medical advice. If you are now taking any drugs, prescribed or not, or have a medical condition, please consult a competent physician who is aware of herb/drug interactions before taking any herbal supplements. The information presented herein has not been evaluated by the FDA or the Department of Health and is not intended to diagnose, prevent or treat any disease or illness.

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Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called  5-methyltetrahydrofolate (5-MTHF).190 Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status191 compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency192 since it requires no conversion to become metabolically active.

People with elevated homocysteine levels have a greater risk of cognitive decline.194 Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12),195 vitamin B6, and riboflavin.196,197


References

References

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