Mitochondrial Basics with BioPQQ 360 mg 30 caps by Life Extension

Mitochondrial Basics with BioPQQ

360 mg 30 caps

Item catalog number: 01769

All cells in our bodies contain tiny organelles called mitochondria that function to produce cellular energy by means of the adenosine triphosphate (ATP) cycle. The number of mitochondria in a cell varies widely by organism and by tissue type. A human cell can have from a few to several thousand mitochondria.

One of the most serious events that cause the loss of cellular vitality is the depletion of mitochondrial energy-producing function. Cells require healthy mitochondrial activity to perform life-sustaining metabolic processes. As mitochondrial function weakens in our cells, so does the vitality of organs such as the heart and brain or in some cases, the entire body.1-6

In order for the mitochondria to create the energy needed to sustain cellular function, fatty acids (which serve as the mitochondria's fuel) must be transported through the cell membrane and into the mitochondria.7-9

Life Extension members now have access to a state-of-the-art nutritional formula called Mitochondrial Energy Optimizer with BioPQQ® that not only protects delicate cellular structures and enables cells to perform life-sustaining metabolic processes . . . it also helps generate new mitochondria. This formula is designed to counteract age-related structural and functional changes and promote biogenesis with these unique ingredients:

  • PQQ (Pyrroloquinoline quinone) — this next generation cellular rejuvenator triggers growth of new mitochondria in aging cells10 and activates genes involved in protecting delicate structures within the mitochondria.11-14
  • R-Lipoic Acid — Free radical activity in the mitochondria plays a major role in the loss of cellular vitality. The microencapsulated Bio-Enhanced® R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.41-46
  • Acetyl-L-Carnitine Arginate — The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. ArginoCarn® Acetyl-L-carnitine arginate is a patented form of carnitine that has been shown in cell cultures to stimulate the growth of neurites.47-49

Taking all of these ingredients separately would be prohibitively expensive. Life Extension members can benefit from all of them in this one cost-effective, comprehensive formulation to promote mitochondrial structure, function and formation.

 

Supplement Facts

Serving Size 1 capsule

Servings Per Container 30

Amount Per Serving

Calcium (as calcium carbonate)

15 mg

Sodium

14 mg

ArginoCarn® Acetyl-L-carnitine arginate dihydrochloride

250 mg

R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate)

100 mg

BioPQQ® Pyrroloquinoline quinone disodium salt

10 mg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, calcium silicate, vegetable stearate, candelilla wax, beeswax.

BioPQQ® is a registered trademark of MGC (Japan).
Bio-Enhanced® is a registered trademark of Geronova Research, Inc.
ArginoCarn® is a registered trademark of Sigma-tau HealthSciences, Inc. and is protected by US patents 6,365,622, US 6,703,042 and EP1202956.

Dosage and Use
  • Take one capsule once or twice daily, preferably early in the day, or as recommended by a healthcare practitioner.
  • This product can be taken with or without food.
  • Refrigerate after opening.
Warnings
  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating
References
1. Biochimie. 1999 Dec;81(12):1131-2.
2. Lancet. 1989 Mar 25;1(8639):642-5.
3. Curr Opin Clin Nutr Metab Care. 2010 Jul 7.
4. Age (Dordr). 2010 Mar 20.
5. Ageing Res Rev. 2010 Jun 25.
6. Ann N Y Acad Sci. 2004 Jun;1019:406-11.
7. Postepy Biochem. 2008;54(2):129-41.
8. Ann N Y Acad Sci. 2002 Apr;959:491-507.
9. Chang Gung Med J. 2009 Mar-Apr;32(2):113-32.
10. Proc Natl Acad Sci USA. 1997 94:3064-9.
11. Ann NY Acad. Sci. 1998; 854:118-27.
12. J Neurosci Res. 2011 Feb;89(2):222-30. 
13. Nature. 2003 Apr 24;422(6934):832.
14. Connect Tissue Res. 1993;29(2):153-61.
15. J Biol Chem. 2010. Jan 1;285:142-152.
16. Alt Med Rev. 2009; 14(3):268-77.
17. Entrez Gene: PARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [Homo sapiens] GeneID: 10891.
18. Entrez Gene: CREBBP CREB binding protein [Homo sapiens] GeneID: 1387.
19. Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, Tchaparian E, Satre M, Karliner JS, Rucker RB. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One. 2011;6(7):e21779. Epub 2011 Jul 21.
20. Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9.
21. FASEB J. 1999 Feb;13(2):411-8.
22. Antioxid Redox Signal. 2000 Fall;2(3):473-83.
23. Biochem Mol Biol Int. 1995 Oct;37(2):361-70.
24. Arch Biochem Biophys. 2004 Mar 1;423(1):126-35.
25. Redox Rep. 2005;10(1):52-60.