Lion’s Mane 60 Veg caps by Host Defense Mushrooms

Lion's Mane is a rare medicinal mushroom that has long been cultivated in Asia. Mycologist Paul Stamets says, "Lion's Mane is nature's nutrient for your neurons." Lion's Mane may be a useful treatment for many conditions of the nervous system such as glaucoma where either neurodegenerative or dementia are involved.**

  • A potent catalyst for brain tissue regeneration.**
  • Helps improve memory and cognitive functions.**
  • Stimulates the synthesis of Nerve Growth Factor in the brain and central nervous system.**
  • May benefit many neurodegenerative or dementia-related diseases such as glaucoma, Alzheimer's, Parkinson's, and multiple sclerosis.
  • Contains high amounts of antioxidants.**
  • Source of immunomodulating beta-glucan.**
  • High in immunomodulating polysaccharides.**
  • Promotes healthy mood and relaxation in menopausal subjects.**
  • Traditionally used to rejuvenate and support the entire nervous system.**
  • Supports digestive tract health.**
  • Promotes mental clarity, focus, and memory*
  • Provides cerebral and nervous system support*
  • Optimizes nervous and immune system health*

Treasured in Vietnam, China and Japan for thousands of years, Lion's Mane is a rare edible medicinal mushroom. Compounds from Lion's Mane can pass the blood-brain barrier and stimulate the production of Nerve Growth Factor in the brain and central nervous system. Lion's Mane may be a useful complementary treatment for conditions of the nervous system where myelin sheaths around the nerve cells suffer damage.**

"Lion's mane is a medicinal mushroom and powerful superfood adaptogen for the brain, nerves and immune system," according to one expert. Used in Asia for thousands of years, it is said to give "nerves of steel and the memory of a lion."

Known for its powerful effects as a brain tonic, Lion's Mane tea has been popular for centuries among Buddhist monks to enhance brain power and heighten their ability to concentrate during meditation.

Experts consider Lion's Mane to be the perfect superfood for those who have experienced seizures because of this ability to elicit nerve regeneration.  It can be extremely helpful for those with epilepsy or who have experienced Gran-mal seizures, both of which are thought to cause nerve cell injury in the brain and affect cognitive function.

These beautiful species, appearing as a white waterfall of cascading icicles, is found on broad leaf trees and logs. The subject of recent studies, Lion’s Mane (Hericium erinaceus) is renowned for providing support to the brain and nervous system.*

Host Defense® Lion’s Mane Capsules use activated, freeze-dried, Certified Organic mycelium, with a full spectrum of constituents: polysaccharides (beta glucans, arabinoxylane, glucose, xylose, galactose and mannose), glycoproteins, ergosterols, triterpenoids and other myco-nutrients,which are essential for Supporting Natural Immunity.*

Lion's Mane Capsules - Host Defense Mushrooms



Keep in a cool dry place, out of the reach of children. If pregnant or nursing, consult your health care professional before using this product.

**DISCLAIMER: Information on this page is not intended as a substitute for advice provided by a competent health care professional. You should not use this information in diagnosing or treating a health problem. No claim or opinion expressed on this web site is intended to be, nor should be construed to be, medical advice. If you are now taking any drugs, prescribed or not, or have a medical condition, please consult a competent physician who is aware of herb/drug interactions before taking any herbal supplements. The information presented herein has not been evaluated by the FDA or the Department of Health and is not intended to diagnose, prevent or treat any disease or illness.


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A comprehensive review of the therapeutic effects of Hericium erinaceus in neurodegenerative disease

Kim*, Herbal Crop Utilization Research Team, Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea Received June 18, 2014, Revised June 20, 2014, Accepted June 25, 2014


Mushrooms are considered not only as food but also for source of physiologically beneficial medicines. The culinarymedicinal mushrooms may important role in the prevention of age-associated neurological dysfunctions, including Alzheimer’s and Parkinson’s diseases. Hericium erinaceus (H. erinaceus), is edible mushrooms, is a parasitic fungus that grows hanging off of logs and trees and well established candidate for brain and nerve health. H. erinaceus contains high amounts of antioxidants, beta-glucan, polysaccharides and a potent catalyst for brain tissue regeneration and helps to improve memory and cognitive functions. Its fruiting bodies and the fungal mycelia exhibit various pharmacological activities, including the enhancement of the immune system, antitumor, hypoglycemic and anti-aging properties. H. erinaceus stimulates the synthesis of Nerve Growth Factor (NGF) which is the primary protein nutrient responsible for enhancing and repairing neurological disorders. Especially hericenones and erinacines isolated from its fruitin body stimulate NGF, synthesis. This fungus is also utilized to regulate blood levels of glucose, triglycerides and cholesterol. H. erinaceus can be considered as useful therapeutic agents in the management and/or treatment of neurodegeneration diseases. However, this review focuses on in vitro, in vivo and clinical trials for neurodegerative disease.


Keywords : Hericium erinaceus, Nerve growth factor, Neurodegenerative disease, Blood-brain barrier


2008 Sep;31(9):1727-32.

Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.

Mori K1, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N.


Neurotrophic factors are essential to maintain and organize neurons functionally; thereby neurotrophic factor-like substances or their inducers are expected to be applied to the treatment of neurodegenerative diseases such as Alzheimer's disease. In the present study, we firstly examined the effects of ethanol extracts of four edible mushrooms, Hericium erinaceus (Yamabushitake), Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Agaricus blazei (Himematsutake), on nerve growth factor (NGF) gene expression in 1321N1 human astrocytoma cells. Among the four mushroom extracts, only H. erinaceus extract promoted NGF mRNA expression in a concentration-dependent manner. In addition, secretion of NGF protein from 1321N1 cells was enhanced by H. erinaceus extracts, and the conditioned medium of 1321N1 cells incubated with H. erinaceus extract enhanced the neurite outgrowth of PC12 cells. However, hericenones C, D and E, constituents of H. erinaceus, failed to promote NGF gene expression in 1321N1 cells. The enhancement of NGF gene expression by H. erinaceus extracts was inhibited by the c-jun N-terminal kinase (JNK) inhibitor SP600125. In addition, H. erinaceus extracts induced phosphorylation of JNK and its downstream substrate c-Jun, and increased c-fos expression, suggesting that H. erinaceus promotes NGF gene expression via JNK signaling. Furthermore we examined the efficacy of H. erinaceus in vivo. ddY mice given feed containing 5% H. erinaceus dry powder for 7 d showed an increase in the level of NGF mRNA expression in the hippocampus. In conclusion, H. erinaceus contains active compounds that stimulate NGF synthesis via activation of the JNK pathway; these compounds are not hericenones.

PMID: 18758067


2013 May 24;10. pii: /j/jcim.2013.10.issue-1/jcim-2013-0001/jcim-2013-0001.xml. doi: 10.1515/jcim-2013-0001.

Hericium erinaceus: an edible mushroom with medicinal values.

Khan MA1, Tania M, Liu R, Rahman MM.


Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for anti-cancer, immuno-modulating, hypolipidemic, antioxidant and neuro-protective activities of this mushroom. H. erinaceus has also been reported to have anti-microbial, anti-hypertensive, anti-diabetic, wound healing properties among other therapeutic potentials. This review article has overviewed the recent advances in the research and study on H. erinaceus and discussed the potential health beneficial activities of this mushroom, with the recognition of bioactive compounds responsible for these medicinal properties.

PMID: 23735479



Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.

Lai PL1, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN.


Neurotrophic factors are important in promoting the growth and differentiation of neurons. Nerve growth factor (NGF) is essential for the maintenance of the basal forebrain cholinergic system. Hericenones and erinacines isolated from the medicinal mushroom Hericium erinaceus can induce NGF synthesis in nerve cells. In this study, we evaluated the synergistic interaction between H. erinaceus aqueous extract and exogenous NGF on the neurite outgrowth stimulation of neuroblastoma-glioma cell NG108-15. The neuroprotective effect of the mushroom extract toward oxidative stress was also studied. Aqueous extract of H. erinaceus was shown to be non-cytotoxic to human lung fibroblast MRC-5 and NG108-15 cells. The combination of 10 ng/mL NGF with 1 μg/mL mushroom extract yielded the highest percentage increase of 60.6% neurite outgrowth. The extract contained neuroactive compounds that induced the secretion of extracellular NGF in NG108-15 cells, thereby promoting neurite outgrowth activity. However, the H. erinaceus extract failed to protect NG108-15 cells subjected to oxidative stress when applied in pre-treatment and co-treatment modes. In conclusion, the aqueous extract of H. erinaceus contained neuroactive compounds which induced NGF-synthesis and promoted neurite outgrowth in NG108-15 cells. The extract also enhanced the neurite outgrowth stimulation activity of NGF when applied in combination. The aqueous preparation of H. erinaceus had neurotrophic but not neuroprotective activities.

PMID: 24266378



Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review).

Wong KH1, Naidu M, David RP, Bakar R, Sabaratnam V.


We present a model case study of the activity of aqueous extract of Hericium erinaceus fresh fruit bodies in promoting functional recovery following crush injury to the peroneal nerve in adult female Sprague-Dawley rats. The aim was to explore the possible use of this mushroom in nerve repair. The activities of aqueous extract were compared to activities exhibited by mecobalamin (vitamin B12), which has been widely used in the treatment of peripheral nerve disorders. Analysis of walking track indicated that return of hind limb function and normal toe spreading occurred earlier in treated groups than in the negative control (non-treated) group. Regeneration of axons and reinnervation of motor endplates/neuromuscular junction in extensor digitorum longus muscle of rats in treated groups developed better than in the negative control group. Further, immunofluorescence studies also showed that dorsal root ganglia neurons ipsilateral to the crush injury in rats of treated groups expressed higher immunoreactivities for Akt and MAPK signaling pathways as well as c-Jun and c-Fos genes compared to the negative control group. Akt cascade plays a major role in mediating neurotrophin-promoted cell survival, while MAPK cascade is involved in mediating neurite outgrowth. Immediate early gene expression was also involved in the cascade of events leading to regeneration. Local axonal protein synthetic machinery was also enhanced in the distal segments of crushed nerves in treated groups. Therefore, daily oral administration of H. erinaceus could promote the regeneration of injured rat peroneal nerve in the early stage of recovery.

PMID: 23510212



The influence of Hericium erinaceus extract on myelination process in vitro.

Kolotushkina EV1, Moldavan MG, Voronin KY, Skibo GG.


Myelin sheaths, wrapping axons, perform the following important functions: support, protection, feeding and isolation. Injury of myelin compact structure leads to an impairment and severe illness of the nerve system. Exact mechanisms underlying the myelination process and myelin sheaths damage have not established yet. Therefore search for substances, which provide regulatory and protective effects on the normal myelination as well as stimulating action on the remyelination after myelin damage, is of special interest. Recently it was shown that extract from mushroom Hericium erinaceus had activating action on the nerve tissue. So the aim of the present work was to study an influence of an extract from H. erinaceus on the cerebellar cells and the process of myelination in vitro. Obtained data revealed the normal growth of the nerve and glial cells with extract at cultivating. No pathologic or toxic action of the extract has been found. The cell ultrastructure was intact and similar to that observed in vivo. The process of myelination in the presence of the extract began earlier as compared to controls and was characterised by a higher rate. Thus, extract of H. erinaceus promoted normal development of cultivated cerebellar cells and demonstrated a regulatory effect on the process of myelin genesis process in vitro.

PMID: 12675022


Nerve Growth Factor-Inducing Activity of <i>Hericium erinaceus</i> in 1321N1 Human Astrocytoma Cells
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A comprehensive review of the therapeutic effects of Hericium erinaceus in neurodegenerative disease
web PDF

About Paradise Herbs & Essentials®

FitEyes knows of no other reputable herbal manufacturer that matches Paradise Herb's full spectrum extraction method combined with raw ingredients of the highest quality and a capsule that is free of fillers and excipients. This is as close to perfection as we have found in a widely available herbal product. For this reason, Paradise Herbs is a featured FitEyes brand that we recommend and trust.

Paradise Herbs & Essentials® Inc. was established in 1994 by our founder and formulator and has been family owned and operated ever since. With a combined experience of over 26 years of training, experience and research in the natural health foods industry along with our founders extensive background in Chinese, Ayurvedic and Euro-Native American herbalism we have established ourselves as a company with big ideas and even higher standards. Our founder has received over ten years of apprentice hands-on training working directly under two Chinese medical doctors with a combined total experience of over sixty years in traditional Chinese medicine.*

At Paradise we know that the end product is only as good as your starting material. We obtain our herbs from special alliances we have built all over the world. Our herbs are grown where they are indigenous; either ethically and ecologically wild crafted or naturally cultivated without the use of any chemical fertilizers, pesticides or preservatives.*

For example: Our Ayurvedic herbs Turmeric, Ashwagandha and Holy Basil are from an isolated and pristine environment at the base of the Himalayans, or we obtain our Ginger from the Ecuadorian rain forest where it is ethically wild crafted. It is this total combination of factors: climate, soil, pristine and natural growing environment that produce the outstanding quality of all our herbs. But we don’t stop there.*

Our end product after extraction is a True Full Spectrum™ extract, although we measure standard marker compounds in most of our extracts we never fractionate or isolate. We believe in keeping all the synergistic components in the balanced ratios nature intended. We know that in many cases it is not evident which components are to be credited for the clinical effect, or if several components must act synergistically, therefore the whole root extract is always regarded as the active ingredient. It is a central philosophy of traditional herbalism to trust in the wisdom of nature to provide the most complete medicines for humans. Unlike the conventional Pharmaceutical Industry that has sought to isolate compounds to create new drugs, we believe the whole herb is the medicine and is supplying all the benefits. For example, studies have shown that a True Full Spectrum™ herbal extract of Panax Ginseng consistently outperforms an extract comprising only isolated ginsenosides. This illustrates that polysaccharides and other active constituents in Ginseng play an integral role in its clinical efficacy. Also, research analysis reveals a component in Panax Ginseng called panaxydol to inhibit cell cycle progression of human malignant tumor cells. We believe this is scientific proof for True Full Spectrum™ preparations as compared to fractionated isolates only containing the ginsenosides and possibly lacking some of the benefits.*

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Common fillers or flow agents like magnesium stearate, calcium stearate or stearic acid are hydrogenated oils (trans fats). Not only are these oils unhealthy, they coat the capsule ingredients with a layer of saturated fat hindering nutrient absorption. Some studies we have seen list this hindrance to be as high as 80%. Doing the math on this, that cuts down nutrient contents utilized to 20%, not very good to say the least.*

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