d-Limonene 1000 mg 60 softgels by Jarrow Formulas

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1000 mg 60 softgels

Item Number: 01034

  • Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine receptors
  • Trabodenoson, a new eye drop in clinical development for the treatment of glaucoma, is said to work on the basis of being an agonistic ligand for adenosine receptors
  • The above two pieces of information make us wonder whether d-Limonene might be beneficial for glaucoma. One FitEyes member, in a preliminary report to our mailing list, thinks d-Limonene may be responsible for his lower eye pressure. He says, "the addition of daily limonene may be part of the reason why my eye pressures have been lower." (Please join the discussion to stay informed of patient feedback with products like this.)
  • Natural Orange Peel Oil
  • Dietary Supplement

Jarrow Formulas d-Limonene is a citrus essential oil that stimulates the liver's Phase I and Phase II detoxifying enzyme systems and supports normal immune function. Jarrow Formulas d-Limonene is steam-distilled from orange peel and is purified to be food grade. d-Limonene is the major constituent of several citrus essential oils (orange, lemon and lime), and naturally occurs in citrus juices.

Suggested Use

Take 1 softgel with or after a meal or as directed by your qualified healthcare professional. If persistent stomach upset occurs, discontinue use.

Other Ingredients

Softgel consists of gelatin, glycerin and water, with caramel and carob (as a light barrier).

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.


Store in a cool, dry place.

Note: If you have a medical condition, are pregnant, lactating, trying to conceive, or taking medications, consult your qualified healthcare professional before using this product.

Keep out of the reach of children.

Supplement Facts
Serving Size: 1 Softgel
Servings Per Container: 60
  Amount Per Serving % DV
d-Limonene (from orange peel oil) 1000 mg *
* Daily Value not established.

How to Manage Symptoms of Gastroesophageal Reflux Disease (GERD) - Life Extension

Q: Are there any natural remedies that effectively manage the symptoms of gastroesophageal distress?

A: Yes. As Life Extension readers may know, d-limonene is an extremely promising natural remedy for managing the symptoms of chronic heartburn and GERD. Derived from the citrus oil contained in orange peel, d-limonene produces fast-acting yet long-lasting relief of the symptoms of gastric distress.

In clinical studies, distilled and purified d-limonene has demonstrated an impressive ability not only to reduce heartburn symptoms, but also to resolve them completely for six months or longer, following a period of treatment as brief as 14 days.6

In one recent trial, approximately 90% of the participants reported complete resolution of their heartburn symptoms just two weeks after beginning supplementation with the orange peel extract.6 The controlled, double-blind second phase of the study showed that those taking orange peel extract experienced a dramatic decrease in the severity of their heartburn symptoms. At the end of the two-week trial period, 83% of those who supplemented with orange peel extract rated their heartburn symptoms no higher than 2 on a scale of 1 (least severe) to 10 (most severe). By comparison, only 30% of the placebo group experienced such benefits. At the end of 20 days, 75% of those taking d-limonene reported relief from heartburn symptoms, compared to only 20% of the subjects who took placebo. No one in the study reported any adverse side effects.6

Q: What experience do you have with d-limonene in the treatment of GERD?

A: D-limonene manages symptoms of GERD in most people, and does so in very short order. Just a limited number of doses—some times as few as two or three—can relieve symptoms for a sustained period of time.

Additionally, research has demonstrated that d-limonene has many biochemical properties that may help guard against cancer and other diseases.7 Another advantage of d-limonene is that it has not been associated with the nutrient deficiencies or impaired digestive function that accompany some acid-blocking drugs. Overall, I think it is a good choice for most people experiencing their first symptoms of GERD.

Q: Do you suggest d-limonene to all your GERD patients?

A: Generally yes, though it depends on particular issues experienced by each patient. Since d-limonene offers quick, lasting relief and is a safe, naturally occurring remedy, I want to offer it to patients with GERD symptoms whenever possible.

Q: Do you sometimes recommend both proton-pump inhibitors and d-limonene?

A: Typically I recommend one or the other. I like to keep things simple, and so do my patients. If my patients use both, it can be difficult for me to determine which therapy is offering the relief. If GERD symptoms are relatively mild, I prefer to begin with d-limonene, since it involves only a brief, finite course of therapy. If patients can achieve effective symptomatic relief from d-limonene, then I think we are way ahead of the game.

Q: What dosage of d-limonene you normally recommend?

A: Normally, I recommend one 1000-mg capsule, every other day, for 20 days, or a total of 10 doses. Of all the over-the-counter medications available to patients, d-limonene is certainly number one on my list. It gives the patients quicker, longer-lasting relief than most anything else, and it is extremely safe.

Roger C. Willette, MD, is an internal medicine specialist in Houston, Texas. Dr. Willette has conducted clinical trials of natural remedies in the management of gastroesophageal symptoms.