Cognizin Citicoline 250 mg 7 caps by Healthy Origins

Temporarily sold out, but more is on the way! Contact us to be notified when available.

Healthy Origins Cognizin Citicoline supports memory function, cognition, healthy brain metabolism and FitEyes members are reporting significant vision improvement in glaucoma. Cognizin Citicoline works by nourishing & maintaining phospholipids in brain cells.

Cognizin® is a patented, branded form of Citicoline, a natural nutrient found in every cell of the body and especially vital to brain health. Unlike artificial stimulants that ramp up energy and attention levels only to have those levels come crashing down later, Cognizin® provides nutritional assistance that helps to:

  • Supports Healthy Cognitive Function
  • Support healthy brain metabolism by nourishing and maintaining phospholipids in brain cells** 1,2,3
  • Maintain normal levels of acetylcholine, an important brain chemical that regulates memory and cognitive function** 4,5
  • Support brain performance by enhancing metabolism and healthy brain activity** 4, 6, 7
  • Sustain your focus and concentration. To sustain your focus and concentration, your brain requires:
    • an adequate ongoing supply of energy
    • healthy communication between neurons.
  • Not only does Cognizin® support healthy brain metabolism, but it also protects your neural structures against free radical damage and provides phospholipids essential to healthy brain function*
Healthy Origins Cognizin is a trademark for Citicoline (CDP Choline), a nutrient that supports healthy cognitive function and sustains healthy brain cell membranes. Cognizin is manufactured using a patented fermentation process which is derived from plant-based, non-GMO materials.

Cognizin Citicoline

250mg, 7 veggie caps

Item Catalog Number: 42020

Healthy Origins Cognizin is a trademark for Citicoline (CDP Choline). Cognizin is manufactured using a patented fermentation process which is derived from plant-based, non-GMO materials.

Suggested Use

As a dietary supplement for adults take one to seven capsules daily with or without food.

Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving % Daily Value
Citicoline (cytidine-5'-diphosphocholine) 250 mg
† Daily Value not established
Other Ingredients

Microcrystalline cellulose, gelatin (capsule), magnesium stearate, silica.

No salt, starch, wheat, gluten, corn, soy, barley, fish, shellfish, nuts, tree nuts, egg or dairy. No artificial sweeteners, flavors, or colors.

Warnings

Keep in a cool dry place, out of the reach of children. If pregnant or nursing, consult your health care professional before using this product.

**DISCLAIMER: Information on this page is not intended as a substitute for advice provided by a competent health care professional. You should not use this information in diagnosing or treating a health problem. No claim or opinion expressed on this web site is intended to be, nor should be construed to be, medical advice. If you are now taking any drugs, prescribed or not, or have a medical condition, please consult a competent physician who is aware of herb/drug interactions before taking any herbal supplements. The information presented herein has not been evaluated by the FDA or the Department of Health and is not intended to diagnose, prevent or treat any disease or illness.

See Discussion tab for more.

Citicoline for Glaucoma Article by Vincenzo Parisi, submitted to FitEyes by Robert Ritch MD

Study references:

1. Lopez-Coviella I et al. J Neurochem. 1995; 65(2):889-94.
2. Conant R, Schauss AG. Alt Med Rev. 2004; 9:1, 17-31.
3. Babb SM et al. Psychopharmacology (Berl). 2002; 161:248-54.
4. Fiorvanti M, Yanagi M. The Cochrane Library, Oxford, England. 2006: Issue 4.
5. Spiers PA et al. Arch Neurol. 1996; 53:441-48.
6. Watanabe S et al. Folia Psychiatr Neurol Jpn. 1975; 29(1):67-76.
7. Silveri MM et al. NMR Biomed. 2008; 21(10):1066-75

Edited FitEyes discussions of citicoline (CDP choline) and glaucoma

Hello FitEyes members. I would like to know about people's results with citicoline. Thanks.

I recently attended The Bascom Palmer’s Eye Institute International Glaucoma meeting in Miami, FL on January 26, 2013 called Glaucoma 2.0: Bench to Bedside where citicholine research was presented.

Citicholine is fantastic! We now have an approved food supplement that can improve retinal and cortical function! I have used intravenous phosphatidylcholine to help patients with severe optic nerve damage but to increase phosphatidylcholine with a food supplement is something I am going to suggest to all my glaucoma patients. Suggest 200 to 1600 mg of Citicoline in divided dosages a day.

Dr. Edward Kondrot

Here is the research I am referring to:

Effect of Citicoline on Glaucomatous Visual Function by Dr. Vincenzo M Parisi (Italy)

In the US, citicoline is marketed as a dietary supplement. Citicoline seems to increase a brain chemical called phosphatidylcholine, which is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured. This study reported that citicoline significantly improves retinal and cortical responses in glaucoma patients, indicating a potential use of this substance in the medical treatment of glaucoma, as a complement to pressure lowering eye drops.
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I have some good news. I am helping a friend who has glaucoma. My friend's eyesight has improved significantly in the last two months. During the last two months, every two weeks she was tested, and every two weeks, she was better. Previously, she could barely see the top line in the eye chart. Now she can read the fourth line down. Her "bad eye" is now her "good eye." At her last visit to the doctor, her ophthalmologist told her that most of the uveitis / inflammation is now gone.

My friend started large doses of citicoline / CDP choline. This has been shown to help repair the retina of the eye. Theoretically, it may also help reduce inflammation because it increases the formation of phosphotidylcholine, which is needed in the repair of any damaged mitochondria membranes. (Repairing the membranes helps to reduce inflammation because when the mitochondria membranes are damaged, inflammatory substances leak out of the mitochondria.)

Citicoline is synthesized by the body from choline and is converted into the important cell membrane compound phosphatidylcholine. In addition, citicoline is available as a dietary supplement. When this supplement is taken, it is converted into choline and cytidine, a component of nucleic acid.
Read more: http://www.livestrong.com/article/478224-citicoline-vs-choline/#ixzz2JpqodoKI

One of the studies cited for citicoline was employing 1000 mg of citicoline per day. My friend is using 2,250 mg.

By the way, you need inositol (another B vitamin) in order for the body to use the choline properly. The inositol also protects the liver from the effects of a lot of choline. My friend has yet to add the inositol.

PH
9/21/12
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What I am confused about is do you still need to take methyl b12 and folic acid because citocoline robs your body of these methyl forms of nutrients?
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No. It isn't necessary to take the methyl-B12 or the methyl-folate when you take citicoline. It might be a good idea though. Methyl-folate also goes by the names of 5-methyltetrahydrofolate, and 5-MTHF.

The citicoline isn't going to rob the methyl groups from the body. However, the body MIGHT rob the methyl groups from the citicoline, thus destroying it. To prevent this from POSSIBLY happening, you would take the methyl-B12 and the methyl-folate. Also, there is some reason to believe that the nerve protective properties of methyl-B12 and methyl-folate MIGHT help you protect your eyesight even if you aren't using the citicoline.
PH
4/28/13
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I take 1750 mg of citicoline per day. I attended the Bascom Palmer Eye Institute seminar (Glaucoma 2.0 From Bench to Bedside) in Miami earlier this year and Dr. Parisi presented his research on the effects of citicoline. His results showed evidence of a neuroprotective role. Visual fields improved for many. I don’t believe it affected IOP. The majority of attendees (mostly MDs/PhDs) thought it a worthwhile supplement. His study used 1600 mg/day oral citicoline but I can find it only in strengths of 500 mg and 250 mg. Apparently it’s safe at high dosages and for taking long term. I started out at a lower dose (500 mg/day) but have been taking it at the 1750 mg dose for ~3 months; subjectively I may be seeing a tiny bit better but this has not been verified by testing. His paper points out that some continued to get improved vision with longer use... “The extension of citicoline treatment up to a period of 8 years lead to the stabilization or improvement of the glaucomatous visual dysfunction. These results suggest potential neuroprotective effects of citicoline in the glaucomatous disease.”
BD
6/6/13
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Citicoline is well known as a brain health nutrient, and now is being counted as a supplement that may significantly slow the progression of visual acuity loss due to glaucoma.

Researchers at the Sao Paolo Hospital Eye Clinic at the University of Milan followed 41 patients with progressing glaucoma — a disease that damages the optic nerve and can lead to vision problems and blindness — over two years. The study targeted individuals with primary open-angle glaucoma (POAG), which is associated with increased eye pressure and a resulting loss of the vision field.

Participants were given an oral solution that contained 500mg of Kyowa citicoline, and the results found the mean rate of progression dropped dramatically compared to the two years prior to the study. The study also found that there was a statistically significant decrease in intraocular pressure. It is not conclusive that citicoline alone is responsible for the results; however supplementation with citicoline may be beneficial in overall brain and eye health.

Citicoline is a vital nutrient that helps the brain generate electrical impulses, care for healthy brain cells, and protect neurons from free radical damage. It supports memory and cognitive function, while aiding in the synthesis and maintenance of cell membranes.

For more information: www.kyowa-usa.com [Editor: Kyowa is the manufacturer of Cognizin, the ingredient in this product.]
M
6/6/13
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I have tried it a few times, but it seems it makes me feel "strange/bad/weak". When I first started to use it I noticed that I did not feel well after taking it. I then stopped taking it and I was ok again. Another attempt and stop caused the same effect. Still not sure if it really is citicoline which is to blame, but it seems so.
Jan
6/10/13
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Hi Jan,
According to the work of Bill Walsh, Phd, if choline bothers you, your reaction might be due to a lack of methyl groups. You might want to try methyl-folate and methyl-B12 and see if you feel better. There are other things that will give you more methyl groups too, like tri-methylglycine (TMG), di-methylglycine (DMG), and SAMe. One of these might be better suited for you. It is hard to say what is best. If you are undermethylated, sometimes high dose inositol is helpful, especially if there are symptoms of Obsessive Compulsive Disorder (OCD).

If you ever get too many methyl groups, you might not feel right, perhaps anxious / wired. In that case, 50 mg of niacinamide may stop the reaction. (The niacinamide mops up methyl groups. ) Don't take too much niacinamide or you will push yourself the other way too far and perhaps feel lethargic and sleepy. It is a balancing act. Everyone has to find their own balance.

If your methionine levels are too high, then the methyl-folate might not agree with you. In this situation, Dr. Ben Lynch suggests trying pyridoxal-5-phosphate (P5P) and magnesium first to help bring methionine levels down. Then you may be able to tolerate the methyl-folate. You may also want to improve your anti-oxidant status. This will help get methylation working in your body again.

PH
6/10/13
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S makes a good suggestion, regarding citicoline. I have started oral use. I am taking the citicoline a step further, and investigating preparation of my own eye drop solution containing citicoline. As I progress, I will advise the Fiteyes folks how it has gone for me. I am not afraid any longer to take my own steps; the medical community for the eyes, makes a snails movement look like Mach speed in comparison. I don't have the luxury of 15 years or so before some pharma and clinical trials get citicoline eye drops on the market.
RR
6/17/13
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The results obtained in the first study (D'Andrea et al. 1989) were further explored in a restricted cohort of selected patients (12 OAG patients only), in which a series of 60 day-periods of treatment each followed by 120 days of wash-out, were carried out during a total period of 8 years.(Parisi 2005) This study showed that after 8 years, glaucomatous patients subjected to citicoline treatment displayed a stable or improved electrophysiological and visual field condition compared to pre-treatment (8 years before), while in similar glaucoma patients without citicoline treatment, there was worsening of the electrophysiological and visual field impairment with respect to pre-treatment conditions (8 years before).
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That's an interesting point regarding the earlier study. I didn't see anything about an episodic treatment regime in this latest study, have I been drifting off again? You could imagine there being a concern over long time use which may have reduced upon the results of the earlier studies.

The 500mg dose used in these latest results interests me for a couple of reasons, firstly, if you were about to start a four year study you would have to think long and hard about the dose, base it on the best available information, and be confidant you're close to the mark to avoid a lot of wasted time and effort.

Second, I read some where, and I find it plausible, that all these supplements that we, the desperate, (those of us who wake up every day knowing we're going to see a little less well today than we did yesterday), search the world for are particularly dose sensitive. The antioxidants, vitamins and coenzymes all have a very narrow band in which they (may) be effective. Imagine a squashed bell curve. A little too much or too little and you've wasted your time, and a few more RGCs.

So....500mg sounds to me like its had a pretty good shakedown, from the previous studies citicoline wouldn't appear to be highly dose sensitive and strikes me as a good place to start. As to the eye drops....I think I'd rather have this stuff washing all over my entire optic pathway!

All the best, Steve.
6/18/13
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I have started taking Citicoline on the advice of my GS. He said there is very little downside!
Follow up:
So far no real change in my IOP since taking Citicoline. However, my GS said it's worth a try to actually improve /stop loss of visual fields.
L
6/18/13
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I have started taken citicoline at 250mg twice daily and have been taking it for three days. I seem to notice a subtle improvement in my mood and perhaps a little more motivation.
I just found does indicate that citicoline might have antidepressant effects. Curious if any others have noticed any difference.
http://www.ncbi.nlm.nih.gov/pubmed/22974472
B
6/25/13
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I've been taking 250 mg of citicoline twice daily for several weeks now. I noticed the mood elevating effect almost immediately and have kept taking it for that reason alone - anything else will be a bonus.
LL
6/26/13
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I too have noticed the energy and mood improved since taking Citicoline. I take 500mg am and pm.
Dr.T
6/26/13
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Also been taking 500mg of citicoline, 250mg twice daily, for 3 weeks now. My visual acuity has improved noticeably both on a contrast test as well as distance vision. Can also easily read the timeclock subtitle for the weekend TV football which I haven't been able to do for quite a long time.

No side effects.

Also night vision seems to have improved although this is only my feeling at the moment no hard evidence.

Mark
2013.07.01
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I have been taking citicoline 250mg twice daily for 7 days now, and I am starting to see a difference in my contrast sensitivity. I have a MARS chart and with enough staring and time, could begin to make out the last 3 letters on the end of the last row (the most faded etc). However, now I can detect them rather quickly.
B
2013.07.01
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Thanks for that great report M. Yes, I too have noticed some sharpening of details on distance viewing and seem to have less blurry vision in general. I also have bad amblyopia in my right eye, but haven't really tested vision in that yet - citicoline is supposed to even help with amblyopia!
B
2013.07.01
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Oral citicoline treatment improves visual pathway function in glaucoma.
Rejdak R, Toczołowski J, Kurkowski J, Kamiński ML, Rejdak K, Stelmasiak Z, Grieb P.
Source

2nd Department of Ophthalmology, Medical University, Lublin, Poland.
Abstract
BACKGROUND:

Increased latency and reduced amplitude of visual evoked potentials (VEP), frequently encountered in ocular hypertension or open-angle glaucoma, suggest slowed neural conduction in the visual pathways. An improvement in VEP latency and amplitude has been reported following repeated intramuscular injections of citicoline, a neuroprotective drug. Our aim was to find whether citicoline given orally would produce a similar effect.
MATERIAL/METHODS:

VEP latency and amplitude were measured in 21 glaucomatous eyes prior to and after two bi-weekly courses of citicoline taken orally in a dose of 1 gram/day. The treatment courses were separated by a two-week break; post-treatment VEP measurement was performed two weeks after the end of the second treatment.
RESULTS:

62% of the eyes showed a response to the treatment, with VEP latency reduced from 123.5 (3.9 SEM) ms to 111.9 (1.9 SEM) ms (P=0.0008), and VEP amplitude increased from 6.56 (1.39 SEM) to 7.88 (1.16 SEM) (P=0.04).
CONCLUSIONS:

Citicoline given orally improves visual evoked potentials in some glaucoma patients.
PMID: 12640353
posted by H
2013.07.02
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Hi. I am thinking of taking citocholine. Webmd stated that it should not be taken for more than 90 days. Is anyone taking this supplemet for a longer period?
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Actually, Webmd does not say that it should not be taken for more than 90 days. It says that it has not been tested for safety beyond 90 days. Here is their statement:

"Citicoline seems to be safe when taken short-term (up to 90 days). The safety of long-term use is not known. Most people who take citicoline don't experience problematic side effects."

However, there have been studies which seem to indicate that it is safe beyond 90 days. Here are the results of a study reporting its use in glaucoma patients over a period of 8 years:

Prog Brain Res. 2008;173:541-54. doi: 10.1016/S0079-6123(08)01137-0.
Evidence of the neuroprotective role of citicoline in glaucoma patients.
(See abstract in next post)

W
2013.07.08
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http://www.ncbi.nlm.nih.gov/pubmed/18929133
Prog Brain Res. 2008;173:541-54. doi: 10.1016/S0079-6123(08)01137-0.
Evidence of the neuroprotective role of citicoline in glaucoma patients.
Parisi V1, Coppola G, Centofanti M, Oddone F, Angrisani AM, Ziccardi L, Ricci B, Quaranta L, Manni G.
Author information
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Here is the abstract:

The glaucomatous disease is currently considered a disease involving ocular and visual brain structures. This new approach to glaucoma introduces the possibility of inducing an improvement by means of a pharmacological approach similar to that used in different degenerative brain disorders. In line with this hypothesis, we studied the effects of oral (1600 mg/die, Cebrolux, Tubilux Pharma, Pomezia, Rome, Italy) or intramuscular (1000 mg/die, Cebroton, Tubilux Pharma) cytidine-5'-diphosphocholine (citicoline) treatment on retinal function and neural conduction in the visual pathways of glaucoma patients with moderate visual defects. Improvement of retinal function (objectively evaluated by pattern electroretinogram recordings) and of neural conduction along visual pathways (objectively evaluated by visual evoked potential recordings) were observed in glaucoma patients after two 60-day periods of oral or intramuscular treatment with citicoline. However, partial regression of this improvement was detected after two 120-day periods of washout. This suggests that the beneficial effects observed are in part treatment-dependent. The extension of citicoline treatment up to a period of 8 years lead to the stabilization or improvement of the glaucomatous visual dysfunction. These results suggest potential neuroprotective effects of citicoline in the glaucomatous disease.

PMID: 18929133
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Yesterday I went to my optometrist for new glasses. Last time I got new glasses was more than two years ago. Something very interesting occurred as I now have a reduced script. He did the test twice and he was a little confused, so was I.

It seems that I can read an additional line with my right eye and two additional lines with my left (for quite a few years I have only been able to read the top letter but it's now three lines). The right eye was easy on the 20 and I think I could have got another line, perhaps even two but he didn't do that.

I think it is partly the Citicoline used over the last two and a bit months as my contrast tests have improved.

So has anybody whom has recently started using Citicoline experienced anything similar? I recall that B stated his contrast tests had also improved?
M
2013.08.22
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Yes M, I did say my contrast had improved on the MARS. In fact, when I mentioned that, you said you were going to do some testing of your own - and thanks for doing so!. What aspect of your accommodation has improved? Where you near sighted, far, presbyopia?
B
2013.08.22
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Far sighted in my right eye. Left eye I don't think anybody knows nor cares as they gave up prescribing for it back in the 1970's. I assume it's short sighted or at least that is the way it was explained to me years ago. Glasses are just a plain clear lens left. I remember when they did prescribe for the left the colour effects gave me many problems to the extent of that I stopped wearing glasses when I was about 16 and got by fine without until about 45 years of age.

As far as accommodation goes I'm corrected right eye both near and far and both have improved. Far more noticeably improved recently as I can probably just about get by without glasses unless I'm tired, actually forgotten them a couple of times when going bicycle riding and didn't notice!
M
2013.08.22
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Interesting M, as I have also noticed better and sharper acuity, and it seems my presbyopia has improved (my refraction is 20/20 but I had been having acuity problems for the past few years). I am quite sure that citicoline has something to do with it.
B
2013.08.22
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Thanks B for confirming those details. It helps my confirmation process that it is just not me. My distance acuity has been quite easily tested by me as I read license plates from a certain distance during my commute and have been doing for at least three years. The readable distance is now much greater but only since starting the Citcoline.
M
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Yes. Yes I am taking Citicoline and my tests have improved not only the actual reading of the chart but the appearance of my eyes. For example the whites of my eyes were gray from the disease process of NTG now the whites of my eyes are white.
Dr.T
2013.08.23
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I have been taking Citicoline for about 2 months now and havent seen any improvement yet in field or acuity. I'm hopeful though. My GS is the wonderful Dr Jeffrey Goldberg who has recently come to UCSD Shiley Eye Center. He said there's enough data to make it worth trying.
Best,
LH
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Is it possible to find out the data Dr. Goldberg is referring to that he feels makes it worth taking?
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Here is a link on the results of a study demonstrating its effectiveness, which was published in the journal Ophthalmology, Vol. 106, No. 6, June 1999.

http://www.vincenzoparisi.it/pdf/Parisi_Ophtalmology_1999.pdf

Dr. Kondrot first reported the benefits of citicoline in a FitEyes post of January 27, 2013 after returning from The Bascom Palmer's Eye Institute International Glaucoma meeting in Miami, FL.:

In the US, citicoline is marketed as a dietary supplement. Citicoline seems to increase a brain chemical called phosphatidylcholine, which is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured. This study reported that citicoline significantly improves retinal and cortical responses in glaucoma patients, indicating a potential use of this substance in the medical treatment of glaucoma, as a complement to pressure lowering eye drops. (Dr Kondrot’s Comments: This is fantastic! An approved food supplement that can improve retinal and cortical function! I have used intravenous phosphatidylcholine to help patients with severe optic nerve damage but to increase phosphatidylcholine with a food supplement is something I am going to suggest to all my glaucoma patients. Suggest 200 to 600 mg of Citicoline in divided dosages a day)
W
2013.08.24
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I have mentioned that I have not seen a noticeable effect yet with citicoline and IOP. However, the Italian study which demonstrated its beneficial role in glaucoma, also mentioned that there 'was' a significant reduction in IOP over the 2 years trial period (though specifics weren't given). Therefore, if anyone doing a citicoline trial notes an IOP reduction, please report. It may take more time than the 2 months I have been on it to see such an effect.
B
2013.08.24
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Some M.D.'s on our Fiteyes site strongly recommended "Cognizin Citicoline" for eyes. I take one capsule, 500mg, each day.
J
2014.03.16
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Citicoline Oral Solution in Glaucoma: Is There a Role in Slowing Disease Progression?
http://www.ncbi.nlm.nih.gov/pubmed/23615390

Abstract

Purpose: To assess the effect of citicoline on visual field rates of progression in patients with progressing glaucoma. Patients and Methods: Forty-one patients with a diagnosis of progressing glaucoma received citicoline in oral solution for 2 years. Included were patients with a disease progression of at least -1 dB/year (at MD, mean deviation) for at least 3 years before entering the study despite controlled intraocular pressure (IOP). Patients were followed with 4 visual field examinations per year for 2 years. Results: At baseline, the mean rate of progression was -1.1 (±0.7) dB/year despite the fact that the IOP had been below 18 mm Hg for at least 3 years. At study inclusion, the mean IOP was 15.5 (±2.6) mm Hg and the mean MD was -9.2 (±6.7) dB in the worst eye. Starting from the first cycle of treatment with citicoline, the mean rate of progression significantly changed to -0.15 (±0.3) dB/year at the end of the study (p = 0.01). Conclusions: This study seems to indicate that supplementation with citicoline might significantly slow down glaucomatous rates of progression.

from B
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Citicoline: A Novel Therapeutic Agent with Neuroprotective, Neuromodulatory, and Neuroregenerative Properties
By Irfan Qureshi, ND, and John R. Endres, ND
http://naturalmedicinejournal.com/journal/2010-06/citicoline-novel-therapeutic-agent-neuroprotective-neuromodulatory-and

A review examining the potential mechanisms through which citicoline exerts its beneficial influence in glaucoma patients theorizes that citicoline’s ability to enhance the synthesis of phosphatidylcholine and other cell-membrane phospholipids is a major factor. Glaucoma is considered a neurodegenerative disease in which the pathology extends to retinal ganglion cells. Death of these cells is likely a result of apoptotic mechanisms. The enhancement of phosphatidylcholine synthesis as a result of citicoline intake counters the neuronal apoptotic mechanisms associated with glaucoma and confers neuroprotection.

Citicoline thus proved to play a beneficial role in this initial study of individuals with ischemic optic neuropathy.
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http://www.cognizin.com/article-citicoline-may-promote-optimal-visual-function.html

Forty patients at simple, primary and chronic stages of glaucoma took part in the study. The group using 1000 mg of Citicoline daily showed marked improvements in visual function during the treatment periods. Furthermore, no adverse side effects were reported with Citicoline. Researchers concluded their results indicated a potential use for Citicoline in medical treatment of glaucoma as a complement to hypotensive therapy.
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Here is an article that says taking CDP choline, also known as citicoline, helps restore eyesight when the eyes have been damaged by glaucoma. http://www.encognitive.com/node/5326
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Oral citicoline treatment improves visual pathway function in glaucoma.
Rejdak R, Toczołowski J, Kurkowski J, Kamiński ML, Rejdak K, Stelmasiak Z, Grieb P.
Source

2nd Department of Ophthalmology, Medical University, Lublin, Poland.
Abstract
BACKGROUND:

Increased latency and reduced amplitude of visual evoked potentials (VEP), frequently encountered in ocular hypertension or open-angle glaucoma, suggest slowed neural conduction in the visual pathways. An improvement in VEP latency and amplitude has been reported following repeated intramuscular injections of citicoline, a neuroprotective drug. Our aim was to find whether citicoline given orally would produce a similar effect.
MATERIAL/METHODS:

VEP latency and amplitude were measured in 21 glaucomatous eyes prior to and after two bi-weekly courses of citicoline taken orally in a dose of 1 gram/day. The treatment courses were separated by a two-week break; post-treatment VEP measurement was performed two weeks after the end of the second treatment.
RESULTS:

62% of the eyes showed a response to the treatment, with VEP latency reduced from 123.5 (3.9 SEM) ms to 111.9 (1.9 SEM) ms (P=0.0008), and VEP amplitude increased from 6.56 (1.39 SEM) to 7.88 (1.16 SEM) (P=0.04).
CONCLUSIONS:

Citicoline given orally improves visual evoked potentials in some glaucoma patients.
PMID: 12640353
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