Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, a naturally occurring compound that plays a significant role in intracellular signaling mechanisms. In both humans and animals, palmitoylethanolamide is produced primarily as a biological repair mechanism, and thus serves as an effective modulator of inflammation and chronic and/or nerve pain. Among the compound’s numerous beneficial mechanisms are neuroprotective and anti-inflammatory capabilities, as well as lipid modulating actions.
To date, no serious side effects or drug-to-drug interactions have been reported as a result of palmitoylethanolamide supplementation.