Black Cumin Seed Oil 60 softgels by Life Extension
FitEyes eStore carries black cumin seed oil because of findings about its benefits for inflammation and the immune system -- two critical factors involved in glaucoma.**
- "Black Cumin is the Most Important Oil You can Put in Your System" - Gary Null, Nutritionist
- Contains hundreds of nutrients
- Natural Dietary Supplement
- It has been used for more than 2000 years treating migraines and other diseases.
- The oil of black cumin was discovered in King Tut’s tomb
As we age, a balanced immune and inflammatory response becomes critical to guarding our health.65-69 Research has shown Black Cumin Seed Oil to be particularly effective.70-78
Scientists have determined that black cumin seeds contain a broad spectrum of active compounds.70 Combined, these compounds provide powerful and wide-ranging immune support and promote healthy inflammatory response.70,71
A number of biological factors contribute to the body’s normal inflammatory activity, including cell-signaling chemicals and hormone-like messengers.77,78 In a series of scientific studies, Black Cumin Seed Oil has been shown to support the normal effectiveness of these inflammatory factors.70,71
Also, an aging, healthy immune system needs to orchestrate the activity of macrophages and helper T-cells. Black Cumin Seed Oil was also shown to support the optimal function of this vitally important defensive activity.79-81
By acting on both immune factors and inflammatory factors, Black Cumin Seed Oil supports a healthy immune system — which is increasingly important as we age — and facilitates a healthy inflammatory response!**
Black Cumin Seed Oil
500 mg, 60 softgels
Item Catalog Number: 01709Suggested Use
Take one softgel twice daily with or without food, or as recommended by a healthcare practitioner.
Thymocid™ is a trademark of Verdure Sciences, Inc.
|Dosage and Use|
To report a serious adverse event or obtain product information, contact 1-866-280-2852
Black Cumin Seed Oil Boosts Immunomodulation
Black cumin seed oil joins a small handful of nutraceuticals now known to modulate the immune system in both directions. In addition to suppressing dangerous chronic inflammation, black cumin seed oil has been shown to boost appropriate immune function. The result is enhanced protection against both infections and cancer.10
In other words, black cumin seed oil offers true immune system balancing, promoting healthy immune function when it's needed, while suppressing excessive immune activity (inflammation), when it's deleterious.
Black cumin seed oil achieves this immunological balancing act by means of several distinct but interrelated mechanisms.
First, black cumin seed oil stimulates actions of patrolling immune system cells on the lookout for invading organisms or abnormal cancer cells. The oil triggers an increase in the activity of macrophages (cells that engulf and destroy abnormal cells) and helper T-cells (cells that marshal natural killer cells and direct them to their targets.)11
Mice injected with the oil were dramatically protected against cytomegalovirus, a version of the herpes virus that can infect humans and cause birth defects and other consequences.11 While control animals still had detectable virus in their systems at 10 days, treated mice were virus-free, the result of enhanced macrophage and T-helper-cell activity.
Thymoquinone, an active component of black cumin seed oil, specifically boosts survival and activity of other key cells in the immune response to infection or cancer, namely so-called CD-8 T-cells.12 These cells are the field troops that actively hunt down and kill infected or cancerous cells, after activation by T-helper and macrophage cells. This activity, known as "conditioning," amplifies the effectiveness of these vital immune system cells against cancer and infectious diseases.12
These effects appear in humans treated with black cumin seed oil as well, according to a study presented at a recent international conference. That study reported a 55% increase in the activity of T-helper cells, and a 30% increase in natural killer cell function, following black cumin seed oil supplementation.13
Black cumin seed oil is a powerful anti-inflammatory agent, capable of suppressing the chronic inflammation that underlies aging and its many symptoms. Now it is showing tremendous promise at combating the gradual loss of immune function we suffer with advancing age. These twin properties give black cumin seed oil unprecedented dual coverage as an age-preventing, health-promoting supplement.
What Is Black Cumin Seed Oil?
Black cumin is one of the most ancient of herbal remedies. Though it has been used as a spice, black cumin should not be confused with common cumin (Cuminum cyminum).5 In many folk traditions, black cumin's antioxidant properties made it an attractive food preservative.5
Oil extracted from black cumin seeds contains a variety of components, all of which have potent free radical scavenging properties.5,7 Of these, thymoquinone is the best understood. In addition to its antioxidant powers, thymoquinone suppresses the activities of enzymes that produce inflammatory cytokines such as interleukins and leukotrienes.
But black cumin seed oil doesn't stop at suppressing inflammation. It contains other powerful ingredients that augment the immune system's patrolling surveillance and "killer" cells responsible for identifying threats such as infection and cancer cells.6
It's this ability to restore balance to the aging immune system that justifies black cumin seed's traditional names "seeds of blessing" and "panacea."5,7
Target the Inflammatory Imbalance of Aging with Black Cumin Seed Oil
- Aging changes the way your immune system functions, increasing inappropriate inflammation while suppressing appropriate immune responses.
- The result of this inflammatory and immunological imbalance is a host of chronic, age-related diseases that contribute to early death.
- The components of black cumin seed oil have unique properties that restore a youthful and optimal inflammatory balance to the immune system's components.
- Through this mechanism, black cumin seed oil has the potential to mitigate—and even reverse—chronic diseases such as arthritis, allergies, asthma, colitis, and cardiovascular disease.
- Studies show that it is possible to achieve a better overall immunological balance, one that promotes health and defeats inflammation, by supplementing with black cumin seed oil.
How Does Black Cumin Seed Oil Work?
Black cumin seed oil is a complex mixture of antioxidant, anti-inflammatory, and immunomodulatory components. These capabilities have made it useful in fighting diseases related both to excessive inflammation (virtually all age-related conditions) and to the impaired immune response of old age.6
Here are the major processes that have been identified as black cumin seed oil's mechanisms of action:
1. Antioxidant: Black cumin seed oil contains powerful antioxidants that reduce intracellular products of oxidation, boost natural cellular antioxidant systems, and scavenge free radicals before they can do harm.6,35
2. Anti-Inflammatory: Black cumin seed oil's constituents that have multiple anti-inflammatory mechanisms:
- Suppress activity of the "master inflammatory regulator" complex NF-kappaB.36
- Inhibit important enzyme systems such as 5-LOX and COX1 that produce inflammatory mediators called leukotrienes and prostaglandins.26,37,38
- Reduce production of a compound called 5-HETE, a precursor of inflammatory molecules.38,39
- Inhibit production and activity of interleukins, cytokines with complex immune modulating properties. Black cumin seed oil constituents reduce production of inflammatory interleukins, and may boost production of anti-inflammatory ones.40-42
3. Immune-Modulating Effects: In addition to suppressing chronic inflammation and free radicals, black cumin oil contributes to beneficial immune responses:
- It boosts the infection- and cancer-fighting abilities of specific cells in the immune system.6,7
- Black cumin seed constituents trigger appropriate activation of pro-inflammatory cytokines in the face of stimulation by dangerous bacterial structural molecules, a function vital for developing acute inflammatory responses to infections.8,9
1. Chung HY, Cesari M, Anton S, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009 Jan;8(1):18-30.
2. Jenny NS, French B, Arnold AM, et al. Long-term assessment of inflammation and healthy aging in late life: The Cardiovascular Health Study All Stars. J Gerontol A Biol Sci Med Sci. 2012 Feb 24. [Epub ahead of print]
3. Franceschi C. Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev. 2007 Dec;65(12 Pt 2):S173-6.
4. Kanapeckiene V, Kalibatas J, Redaitiene E, Ceremnych J. The association between cytomegalovirus infection and aging process. Medicina (Kaunas). 2007;43(5):419-24.
5. Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008;6(b):495-510.
6. Shahzad M, Yang X, Raza Asim MB, et al. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther. 2009 Feb;22(1):37-43. Epub 2008 Nov 27.
7. Butt MS, Sultan MT. Nigella sativa: reduces the risk of various maladies. Crit Rev Food Sci Nutr. 2010 Aug;50(7):654-65.
8. Finlay TM, Abdulkhalek S, Gilmour A, et al. Thymoquinone-induced Neu4 sialidase activates NFkappaB in macrophage cells and pro-inflammatory cytokines in vivo. Glycoconj J. 2010 Aug;27(6):583-600.
9. Finlay TM, Jayanth P, Amith SR, et al. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconj J. 2010 Apr;27(3):329-48.
10. Majdalawieh AF, Hmaidan R, Carr RI. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J Ethnopharmacol. 2010 Sep 15;131(2):268-75. Epub 2010 Jun 30.
11. Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol. 2000 Sep;22(9):729-40.
12. Salem ML, Alenzi FQ, Attia WY. Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro. Br J Biomed Sci. 2011;68(3):131-7.
13. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005 Dec;5(13-14):1749-70.
14. Available at: http://www.sciencedaily.com/releases/2011/04/110419091159.htm. Accessed August 2, 2012.
15. Chen WP, Tang JL, Bao JP, Wu LD. Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis. Exp Biol Med (Maywood). 2010 Dec;235(12):1425-31.
16. Available at: http://www.cdc.gov/nchs/fastats/arthrits.htm. Accessed July 12, 2012.
17. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa Oil in the Management of Rheumatoid Arthritis Patients: A Placebo Controlled Study. Phytother Res. 2011 Dec 12.
18. Available at: http://www.cdc.gov/Features/dsArthritis/. Accessed July 12, 2012.
19. Available at: http://www.cdc.gov/nchs/fastats/allergies.htm. Accessed July 12, 2012.
20. Available at: http://www.cdc.gov/nchs/fastats/asthma.htm . Accessed July 12, 2012.
21. Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chem Biol Interact. 2012 Apr 15;197(1):40-6.
22. Abbas AT, Abdel-Aziz MM, Zalata KR, Abd Al-Galel Tel D. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Immunol. 2005;12(1):95-102.
23. Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N. Herbal treatment of allergic rhinitis: the use of Nigella sativa. Am J Otolaryngol. 2011 Sep-Oct;32(5):402-7.
24. Al-Majed AA, Daba MH, Asiri YA, Al-Shabanah OA, Mostafa AA, El-Kashef HA. Thymoquinone-induced relaxation of guinea-pig isolated trachea. Res Commun Mol Pathol Pharmacol. 2001;110(5-6):333-45.
25. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol. 2006 Jul;6(7):1135-42.
26. El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC. Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim Biophys Acta. 2006 Jul;1760(7):1088-95.
27. Available at: http://www.cdc.gov/ibd/. Accessed July 12, 2012.
28. Mahgoub AA. Thymoquinone protects against experimental colitis in rats. Toxicol Lett. 2003 Jul 20;143(2):133-43.
29. Isik F, Tunali Akbay T, Yarat A, et al. Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. Dig Dis Sci. 2011 Mar;56(3):721-30.
30. Kanter M, Demir H, Karakaya C, Ozbek H. Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J Gastroenterol. 2005 Nov 14;11(42):6662-6.
31. Abdel-Sater KA. Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol. 2009;1(2):143-49.
32. Al-Naqeep G, Al-Zubairi AS, Ismail M, Amom ZH, Esa NM. Antiatherogenic potential of Nigella sativa seeds and oil in diet-induced hypercholesterolemia in rabbits. Evid Based Complement Alternat Med. 2011;2011:213628.
33. Nader MA, el-Agamy DS, Suddek GM. Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharm Res. 2010 Apr;33(4):637-43. Epub 2010 Apr 27.
34. Bayrak O, Bavbek N, Karatas OF, et al. Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys. Nephrol Dial Transplant. 2008 Jul;23(7):2206-12.
35. Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2012 Feb 15;83(4):443-51.
36. Sethi G, Ahn KS, Aggarwal BB. Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res. 2008 Jun;6(6):1059-70.
37. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995 Feb;61(1):33-6.
38. Mansour M, Tornhamre S. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. J Enzyme Inhib Med Chem. 2004 Oct;19(5):431-6.
39. El-Dakhakhny M, Madi NJ, Lembert N, Ammon HP. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol. 2002 Jul;81(2):161-4.
40. Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, Benderdour M. Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. J Cell Biochem. 2011 Jan;112(1):107-17.
41. Keyhanmanesh R, Boskabady MH, Khamneh S, Doostar Y. Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs. Pharmacol Rep. 2010 Sep-Oct;62(5):910-6.
42. Nemmar A, Al-Salam S, Zia S, et al. Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone. Br J Pharmacol. 2011 Dec;164(7):1871-82.
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